Layman’s summary: Tubulo-interstitial nephropathy is a disease process found in many patients especially those who have been on dialysis for long periods of time. In research on rats, there is a possible suggestion that dietary changes can affect the causes of the disease and alleviate symptoms.
Publication date: February 2013
Published in: Nephrology Dialysis Transplantation
Lead author: Mohammed A. Aminzadeh
University of California Irvine

Abstract: Tubulo-interstitial nephropathy (TIN) is a common cause of chronic kidney disease (CKD). Consumption of an adenine-containing diet causes the accumulation of 2,8-dihydroxyadenine in the renal tubules triggering intense chronic TIN and progressive CKD in rats. CKD in this model is associated with, and largely driven by, oxidative stress and inflammation.

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