|Layman’s summary:||Tubulo-interstitial nephropathy is a disease process found in many patients especially those who have been on dialysis for long periods of time. In research on rats, there is a possible suggestion that dietary changes can affect the causes of the disease and alleviate symptoms.|
|Publication date:||February 2013|
|Published in:||Nephrology Dialysis Transplantation|
|Lead author:||Mohammed A. Aminzadeh
University of California Irvine
Abstract: Tubulo-interstitial nephropathy (TIN) is a common cause of chronic kidney disease (CKD). Consumption of an adenine-containing diet causes the accumulation of 2,8-dihydroxyadenine in the renal tubules triggering intense chronic TIN and progressive CKD in rats. CKD in this model is associated with, and largely driven by, oxidative stress and inflammation.